US Patent Issued to The Regents of the University of California on Sept. 16 for "RNA-guided endonuclease fusion polypeptides and methods of use thereof" (California Inventor)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,415,993, issued on Sept. 16, was assigned to The Regents of the University of California (Oakland, Calif.).

"RNA-guided endonuclease fusion polypeptides and methods of use thereof" was invented by Schaked Omer Halperin (Berkeley, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a fusion polypeptide comprising: a) an enzymatically active RNA-guided endonuclease that introduces a single-stranded break in a target DNA; and b) an error-prone DNA polymerase. The present disclosure provides a system comprising: a) a fusion polypeptide of the present disclosure; and b) a guide RNA. The present disclosure provides a cell co...