US Patent Issued to The Regents of the University of California on Nov. 4 for "G-protein-coupled receptor internal sensors" (California Inventors)

ALEXANDRIA, Va., Nov. 6 -- United States Patent no. 12,459,985, issued on Nov. 4, was assigned to The Regents of the University of California (Oakland, Calif.).

"G-protein-coupled receptor internal sensors" was invented by Lin Tian (Davis, Calif.), Tommaso Patriarchi (Davis, Calif.) and Ruqiang Liang (Davis, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are circularly permuted fluorescent protein sensors useful to integrate into the third intracellular loop of a G protein-coupled receptor (GPCR). Also provided are GPCRs having a circularly permuted fluorescent protein sensor integrated into its third intracellular loop and methods of using such GPCRs, e.g., to screen for GPCR agonists and an...