US Patent Issued to The Regents of the University of California on Jan. 13 for "Mild and site-selective 18F-labeling of small molecules and/or biomolecules via a thiol- reactive synthon" (California Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,521,453, issued on Jan. 13, was assigned to The Regents of the University of California (Oakland, Calif.).

"Mild and site-selective 18F-labeling of small molecules and/or biomolecules via a thiol- reactive synthon" was invented by Jennifer M. Murphy (Los Angeles) and Gaoyuan Ma (Irvine, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Site-selective conjugation to biomolecules via thiol-based chemistry is superior to the unselective modification of lysine residues, which produce a mixed product and can potentially interfere with binding affinity of the biomolecule. However, in physiological environments, the maleimide-thiol conjugation product whic...