US Patent Issued to The Regents of the University of California on Aug. 26 for "Targeted replacement of endogenous T cell receptors" (California Inventors)

ALEXANDRIA, Va., Aug. 26 -- United States Patent no. 12,398,193, issued on Aug. 26, was assigned to The Regents of the University of California (Oakland, Calif.).

"Targeted replacement of endogenous T cell receptors" was invented by Theodore Lee Roth (San Francisco), Eric Shifrut (San Francisco), Alexander Marson (San Francisco), Cristina Puig Saus (Los Angeles) and Antoni Ribas (Los Angeles).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-Beta chain and a heterologous TCR-Alpha chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell....