US Patent Issued to The Regents of the University of California, Technical University of Denmark on Aug. 5 for "Asparaginase based selection system for heterologous protein expression in mammalian cells" (American, Danish Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,573, issued on Aug. 5, was assigned to The Regents of the University of California (Oakland, Calif.) and Technical University of Denmark (Kongens Lyngby, Denmark).

"Asparaginase based selection system for heterologous protein expression in mammalian cells" was invented by Hooman Hefzi (Cambridge, Mass.), Nathan E. Lewis (San Diego), Karen Julie la Cour Karottki (Cambridge, Mass.) and Helene Faustrup Kildegaard (Vaerlose, Denmark).

According to the abstract* released by the U.S. Patent & Trademark Office: "A non-naturally occurring cell comprising an inoperative genomic asparaginase (Aspg) gene and an inoperative glutamine synthetase (Gs) gene, wherein the cell has been transfected...