US Patent Issued to The Regents of the University of California, Seattle Children's Hospital on Feb. 25 for "Bispecific or-gate chimeric antigen receptor responsive to CD20 and CD19" (California, Washington Inventors)

ALEXANDRIA, Va., Feb. 26 -- United States Patent no. 12,233,090, issued on Feb. 25, was assigned to The Regents of the University of California (Oakland, Calif.) and Seattle Children's Hospital (Seattle).

"Bispecific or-gate chimeric antigen receptor responsive to CD20 and CD19" was invented by Yvonne Y. Chen (Los Angeles), Eugenia Zah (Los Angeles) and Michael C. Jensen (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "A CD20-OR-CD19 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD20-OR-CD19 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD20-OR-CD19 CAR of the invention is a bispecific CAR that can trigger T-cel...