US Patent Issued to The Medical College of Wisconsin on Aug. 5 for "Gene expression signature of hyperprogressive disease (HPD) in patients after anti-PD-1 immunotherapy" (Wisconsin Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,380,963, issued on Aug. 5, was assigned to The Medical College of Wisconsin Inc. (Milwaukee).

"Gene expression signature of hyperprogressive disease (HPD) in patients after anti-PD-1 immunotherapy" was invented by Donghai Xiong (Franklin, Wis.), Ming You (Elm Grove, Wis.) and Yian Wang (Milwaukee).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method of determining a patient's HPD status comprising the steps of a) examining a patient tumor sample for the expression level of HPD-diagnostic biomarkers, and b) determining whether the signature of the biomarkers is similar to that of a HPD positive signature is disclosed."

The patent was filed on Oct. 14, ...