US Patent Issued to The General Hospital on April 29 for "Methods for increasing efficiency of nuclease-induced homology-directed repair" (Massachusetts, Tennessee, California Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,286,641, issued on April 29, was assigned to The General Hospital Corp. (Boston).

"Methods for increasing efficiency of nuclease-induced homology-directed repair" was invented by J. Keith Joung (Cambridge, Mass.), Benjamin Kleinstiver (Medford, Mass.), Jason Michael Gehrke (Santa Barbara, Calif.), Shengdar Tsai (Memphis, Tenn.), James Angstman (Cambridge, Mass.) and Rebecca Tayler Cottman (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ)."

The pat...