US Patent Issued to THE CHILDREN'S MEDICAL CENTER, UNIVERSITY OF MASSACHUSETTS on Jan. 13 for "Enhanced BCL11A RNP / CRISPR delivery and editing using a 3XNLS-CAS9" (American, Chinese Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,811, issued on Jan. 13, was assigned to THE CHILDREN'S MEDICAL CENTER Corp. and UNIVERSITY OF MASSACHUSETTS.

"Enhanced BCL11A RNP / CRISPR delivery and editing using a 3XNLS-CAS9" was invented by Daniel E. Bauer (Cambridge, Mass.), Scot A. Wolfe (Winchester, Mass.), PengPeng Liu (Worcester, Mass.), Yuxuan Wu (Boston) and Jing Zeng (Chongqing, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are synthetic nucleic acids that encode a CRISPR enzyme fused to a series of nuclear localization signal sequences for the use of altering expression of a gene in a cell. Further provided herein are methods for altering gene expression in a ce...