US Patent Issued to The Broad Institute, President and Fellows of Harvard College on Nov. 18 for "Adenine base editors with reduced off-target effects" (Massachusetts Inventors)

ALEXANDRIA, Va., Nov. 18 -- United States Patent no. 12,473,543, issued on Nov. 18, was assigned to The Broad Institute Inc. (Cambridge, Mass.) and President and Fellows of Harvard College (Cambridge, Mass.).

"Adenine base editors with reduced off-target effects" was invented by David R. Liu (Cambridge, Mass.) and Holly A. Rees (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides novel adenine base editors that retain ability to edit DNA efficiently but show greatly reduced off-target effects, such as reduced RNA editing activity, as well as lower off-target DNA editing activity and reduced indel by product formation. Also provided are base editing methods comprisi...