US Patent Issued to THE BROAD INSTITUTE, Massachusetts Institute of Technology, THE BRIGHAM AND WOMEN'S HOSPITAL on Oct. 21 for "Modulation of novel immune checkpoint targets" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,447,213, issued on Oct. 21, was assigned to THE BROAD INSTITUTE INC. (Cambridge, Mass.), Massachusetts Institute of Technology (Cambridge, Mass.) and THE BRIGHAM AND WOMEN'S HOSPITAL INC. (Boston).

"Modulation of novel immune checkpoint targets" was invented by Vijay K. Kuchroo (Newton, Mass.), Ana Carrizosa Anderson (Brookline, Mass.), Asaf Madi (Boston), Norio Chihara (Boston), Aviv Regev (Cambridge, Mass.), Meromit Singer (Cambridge, Mass.) and Huiyuan Zhang (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Dysfunctional or exhausted T cells arise in chronic diseases including chronic viral infections and cancer, and express high levels of co-in...