US Patent Issued to THE BROAD INSTITUTE, DANA-FARBER CANCER INSTITUTE on May 13 for "DNA damage response signature guided rational design of CRISPR-based systems and therapies" (Massachusetts Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,426, issued on May 13, was assigned to THE BROAD INSTITUTE INC. (Cambridge, Mass.) and DANA-FARBER CANCER INSTITUTE INC. (Boston).

"DNA damage response signature guided rational design of CRISPR-based systems and therapies" was invented by Uri Ben-David (Cambridge, Mass.), Todd Golub (Cambridge, Mass.), Rameen Beroukhim (Boston), Oana Enache (Cambridge, Mass.) and Veronica Rendo (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are embodiments of methods to rationally design CRISPR-Cas system-based therapeutics and therapies based on expression of a DNA-damage response signature in a cell. In some embodiments, the methods inclu...