US Patent Issued to THE BRIGHAM AND WOMEN'S HOSPITAL, THE BROAD INSTITUTE, Massachusetts Institute of Technology on March 4 for "Modulation of novel immune checkpoint targets" (Massachusetts Inventors)

ALEXANDRIA, Va., March 5 -- United States Patent no. 12,241,053, issued on March 4, was assigned to THE BRIGHAM AND WOMEN'S HOSPITAL INC. (Boston), THE BROAD INSTITUTE INC. (Cambridge, Mass.) and Massachusetts Institute of Technology (Cambridge, Mass.).

"Modulation of novel immune checkpoint targets" was invented by Vijay K. Kuchroo (Boston), Ana C. Anderson (Boston), Asaf Madi (Boston), Norio Chihara (Boston), Aviv Regev (Cambridge, Mass.) and Meromit Singer (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Dysfunctional or exhausted T cells arise in chronic diseases including chronic viral infections and cancer, and express high levels of co-inhibitory receptors. Therapeutic blockade of thes...