US Patent Issued to The Board of Trustees of the University of Illinois on Feb. 25 for "Fluorescent substrates for poly(ADP-ribosyl) hydrolases" (Illinois Inventors)

ALEXANDRIA, Va., Feb. 26 -- United States Patent no. 12,235,275, issued on Feb. 25, was assigned to The Board of Trustees of the University of Illinois (Urbana, Ill.).

"Fluorescent substrates for poly(ADP-ribosyl) hydrolases" was invented by Paul J. Hergenrother (Champaign, Ill.) and Bryon S. Drown (Champaign, Ill.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Disclosed herein is a substrate for monitoring PARG activity, TFMU-AD...