US Patent Issued to The Board of Regents of the University of Oklahoma on July 1 for "Clostridioides difficile TcdB variants, vaccines and methods of use" (Oklahoma Inventors)

ALEXANDRIA, Va., July 3 -- United States Patent no. 12,343,388, issued on July 1, was assigned to The Board of Regents of the University of Oklahoma (Norman, Okla.).

"Clostridioides difficile TcdB variants, vaccines and methods of use" was invented by Jimmy D. Ballard (Norman, Okla.) and Sarah J. Bland (Oklahoma City).

According to the abstract* released by the U.S. Patent & Trademark Office: "An immunogenic composition comprising a deletion mutant of a Clostridioides difficile TcdB toxin (such as TcdB2 or TcdB1) that lacks residues at least from amino acid residue 1769 to amino acid residue 1787 of a wild-type TcdB amino acid sequence or of a protein having high identity thereto, a vaccine comprising the immunogenic composition, a method...