ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,441,724, issued on Oct. 14, was assigned to Takeda Pharmaceutical Co. Ltd. (Osaka, Japan).

"Inhibitors of plasma kallikrein and uses thereof" was invented by Nikolaos Papaioannou (Newton, Mass.), Sarah Jocelyn Fink (Arlington, Mass.), Thomas Allen Miller (Wakefield, Mass.), Gerald Wayne Shipps Jr. (Stoneham, Mass.), Jeremy Mark Travins (Southborough, Mass.), David Edward Ehmann (Lexington, Mass.), Alastair Rae (Saffron Walden, Great Britain) and John Mark Ellard (Buntingford, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein a...