US Patent Issued to STOKE THERAPEUTICS on June 24 for "OPA1 antisense oligomers for treatment of conditions and diseases" (Massachusetts Inventors)

ALEXANDRIA, Va., June 25 -- United States Patent no. 12,338,437, issued on June 24, was assigned to STOKE THERAPEUTICS INC. (Bedford, Mass.).

"OPA1 antisense oligomers for treatment of conditions and diseases" was invented by Isabel Aznarez (Boston), Aditya Venkatesh (Natick, Mass.) and Gene Liau (Wayland, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Alternative splicing events in genes can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in genes can modulate the expression level of functional proteins in patients and/or inhibit aberrant protein expression. Such therapeutic agents ca...