US Patent Issued to Seattle Children's Hospital on May 27 for "Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors" (Washington Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,416, issued on May 27, was assigned to Seattle Children's Hospital (Seattle).

"Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors" was invented by Michael C. Jensen (Bainbridge Island, Wash.) and James F. Matthaei (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects described herein pertain to engineered chimeric antigen receptors (CARs) and compositions thereof having specificity and affinity for fluorescein containing ligands presented on the surface of tumor cells. Also provided herein are compositions including CARs further comprising a spacer arm and methods of making and using these compositi...