ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,427,142, issued on Sept. 30, was assigned to Sanofi (Paris).

"Combination comprising alpelisib and 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl[oxyphenyl-8,9-dihydro-7H-benzo[7annulene-2-carboxylic acid" was invented by Monsif Bouaboula (Belmont, Mass.), Zhuyan Guo (Belmont, Mass.), Stephane Poirier (Stoneham, Mass.), Maysoun Shomali (Belmont, Mass.) and Fangxian Sun (Melrose, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein are provided a combination of alpelisib and of 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid or a pharmaceutically...