US Patent Issued to Rottapharm Biotech on Feb. 10 for "Pharmaceutical combination of an EP4 antagonist and immune checkpoint inhibitors for the treatment of tumours" (Italian Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,544,365, issued on Feb. 10, was assigned to Rottapharm Biotech S.R.L. (Monza, Italy).

"Pharmaceutical combination of an EP4 antagonist and immune checkpoint inhibitors for the treatment of tumours" was invented by Lucio Claudio Rovati (Monza, Italy), Antonio Giordani (Pavia, Italy), Filippo Magaraci (Monza, Italy), Gianfranco Caselli (Milan), Tiziana Piepoli (Milan), Daniele Maggioni (Barzio, Italy) and Albino Bonazzi (Milan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a pharmaceutical combination comprising the EP4 antagonist of Formula (R)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopro...