US Patent Issued to Research Institute at Nationwide Children's Hospital on March 25 for "Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy" (Ohio Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,573, issued on March 25, was assigned to Research Institute at Nationwide Children's Hospital (Columbus, Ohio).

"Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy" was invented by Louise Rodino-Klapac (Grove City, Ohio), Danielle Griffin (Canal Winchester, Ohio) and Jerry R. Mendell (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are methods of treating muscular dystrophy in a subject, comprising administration of a recombinant AAV vector AAVrh74.tMCK.hSGCA using a systemic route of administration and at a dose of about 1.0x1012 vg/kg to about 5.0x1015 vg/kg. Further ...