US Patent Issued to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL on Feb. 10 for "DUX4 RNA silencing using RNA targeting CRISPR-CAS13b" (Ohio Inventors)

ALEXANDRIA, Va., Feb. 11 -- United States Patent no. 12,545,909, issued on Feb. 10, was assigned to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio).

"DUX4 RNA silencing using RNA targeting CRISPR-CAS13b" was invented by Scott Quenton Harper (Powell, Ohio) and Afrooz Rashnonejad (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "RNA interference-based nucleic acids encoding double homeobox 4 (DUX4)-encoding guide RNAs (gRNA), or gRNAs that specifically hybridize to a target nucleic acid encoding DUX4 and methods for inhibiting the expression of DUX4 using the gRNAs and Cas13 are provided. The methods have application in the treatment of muscular dystrophies including, but not...