US Patent Issued to Research Institute at Nationwide Children's Hospital on Dec. 9 for "Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy" (Ohio Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,491,265, issued on Dec. 9, was assigned to Research Institute at Nationwide Children's Hospital (Columbus, Ohio).

"Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy" was invented by Louise Rodino-Klapac (Grove City, Ohio) and Jerry R. Mendell (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides gene therapy vectors, such as adeno-associated virus (AAV) vectors, expressing a miniaturized human micro-dystrophin gene and method of using these vectors to express micro-dystrophin in skeletal muscle s including diaphragm and cardiac muscle and to protect muscle fibers from in...