ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,377,051, issued on Aug. 5, was assigned to REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Mich.).

"Microspheres for extended, controlled release of therapeutic agents" was invented by Steven P. Schwendeman (Superior Township, Mich.) and Jie Tang (Ann Arbor, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure relates to microspheres comprising a core and a shell. More particularly the disclosure relates to microspheres for extended, controlled release of a poorly water-soluble therapeutic agent having a solubility in water of 50 Mug/mL or less, the microsphere having a core comprising the therapeutic agent, and a substantially impermeab...