US Patent Issued to Regeneron Pharmaceuticals on Jan. 13 for "CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy" (New York, New Jersey Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,521,451, issued on Jan. 13, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy" was invented by Charleen Hunt (Montvale, N.J.), Yang Liu (Valhalla, N.Y.), Guochun Gong (Pleasantville, N.Y.), Carmelo Romano (Tarrytown, N.Y.) and Brian Zambrowicz (Sleepy Hollow, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Nucleic acid constructs and compositions that allow insertion and/or expression of a retinoschisin coding sequence are provided. Nuclease agents targeting RS1 loci are provided. Compositions and methods of using such constructs for integration into a target geno...