US Patent Issued to Regeneron Pharmaceuticals on Dec. 30 for "Heavy chain constant regions with reduced binding to Fc gamma receptors" (New York, New Jersey Inventors)

ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,516, issued on Dec. 30, was assigned to Regeneron Pharmaceuticals Inc. (Tarrytown, N.Y.).

"Heavy chain constant regions with reduced binding to Fc gamma receptors" was invented by Samuel Davis (New York), Eric Smith (New York), Tong Zhang (Fort Lee, N.J.) and Supriya Patel (Mamaroneck, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides antibody heavy chain constant regions with a hinge region modified to reduce binding to FcGamma receptors. The modification occurs within positions 233-236 by replacement of natural residues by glycine(s) and/or deletion(s). Such modifications can reduce binding of an antibody bearing such a co...