ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,448,518, issued on Oct. 21, was assigned to RAKUTEN MEDICAL INC. (San Diego).

"Phthalocyanine dye compounds, conjugates and methods of use thereof" was invented by Juan Betancort (San Diego), Lew Makings (Encinitas, Calif.), Torsten Wiemann (Encinitas, Calif.) and Robert J. Hoey (Santee, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are phthalocyanine dyes, and conjugates thereof, useful as fluorescent reporters for bioassays, for optical imaging and as therapeutic conjugates as the photosensitizing agents in light-based therapies including photoimmuno therapy (PIT). Certain phthalocyanine dyes disclosed herein are water soluble...