US Patent Issued to President and Fellows of Harvard College on Oct. 7 for "Cytosine to guanine base editor" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,331, issued on Oct. 7, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Cytosine to guanine base editor" was invented by David R. Liu (Cambridge, Mass.) and Luke W. Koblan (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Some aspects of this disclosure provide compositions, strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins capable of inducing a cytosine (C) to guanine (G) change in a nucleic acid (e.g., genomic ...