US Patent Issued to President and Fellows of Harvard College on April 15 for "Cellular reprogramming to reverse aging and promote organ and tissue regeneration" (Massachusetts Inventors)

ALEXANDRIA, Va., June 5 -- United States Patent no. 12,274,733, issued on April 15, was assigned to President and Fellows of Harvard College (Cambridge, Mass.).

"Cellular reprogramming to reverse aging and promote organ and tissue regeneration" was invented by David A. Sinclair (Cambridge, Mass.) and Yuancheng Lu (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are engineered nucleic acids (e.g., expression vectors, including viral vectors, such as lentiviral vectors, adenoviral vectors, AAV vectors, herpes viral vectors, and retroviral vectors) that encode OCT4; KLF4; SOX2; or any combination thereof that are useful, for example, in inducing cellular reprogramming, tissue rep...