US Patent Issued to Ospedale San Raffaele, Fondazione Telethon on Dec. 2 for "Method for improving retroviral transduction and gene editing in hematopoietic stem cells using clyclosporin H and UM171" (Italian Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,485,187, issued on Dec. 2, was assigned to Ospedale San Raffaele S.R.L. (Milan) and Fondazione Telethon (Rome).

"Method for improving retroviral transduction and gene editing in hematopoietic stem cells using clyclosporin H and UM171" was invented by Anna Christina Kajaste-Rudnitski (Milan), Carolina Petrillo (Milan), Bernhard Rudolf Gentner (Milan), Luigi Naldini (Milan), Pietro Genovese (Milan) and Giulia Schiroli (Milan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Use of cyclosporin H (CsH) or a derivative thereof for increasing the efficiency of transduction of an isolated population of cells by a viral vector and/or increasing the efficiency of ge...