US Patent Issued to Ohio State Innovation Foundation on June 17 for "Peptidyl inhibitors of calcineurin-NFAT interaction" (Ohio Inventors)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,329,799, issued on June 17, was assigned to Ohio State Innovation Foundation (Columbus, Ohio).

"Peptidyl inhibitors of calcineurin-NFAT interaction" was invented by Dehua Pei (Columbus, Ohio), John W. Christman (Columbus, Ohio), Manjula Karpurapu (Columbus, Ohio) and Patrick G. Dougherty (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-...