ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,440,440, issued on Oct. 14, was assigned to Novohale Therapeutics LLC (San Diego).

"Dry powder esketamine composition for use in the treatment of bipolar depression by pulmonary administration" was invented by Maciej Wieczorek (Kielpin, Poland), Ewa Tratkiewicz (Warsaw, Poland) and Przemyslaw Perko (Warsaw, Poland).

According to the abstract* released by the U.S. Patent & Trademark Office: "A dry powder inhalable pharmaceutical composition comprising ketamine or its pharmaceutically acceptable salt for use in a method of treatment of depression by administration via pulmonary route. The composition is especially useful for the treatment of treatment-resistant or treatment-refractory ...