US Patent Issued to Northwestern University on Dec. 9 for "Substituted 3-amino-5-phenylbenzamide compounds as covalent inhibitors of enhancer zeste homolog 2 (EZH2) and proteolysis-targeting chimeric derivatives thereof (PROTACs) that induce degradation of EZH2" (Illinois Inventors)

ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,491,252, issued on Dec. 9, was assigned to Northwestern University (Evanston, Ill.).

"Substituted 3-amino-5-phenylbenzamide compounds as covalent inhibitors of enhancer zeste homolog 2 (EZH2) and proteolysis-targeting chimeric derivatives thereof (PROTACs) that induce degradation of EZH2" was invented by Gary E. Schiltz (Naperville, Ill.) and Jindan Yu (Evanston, Ill.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are covalent inhibitors of enhancer zeste homolog 2 (EZH2) which may be utilized as EZH2 targeting agents. The disclosed compounds may be characterized as substituted 3-amino-5-phenylbenzamide compounds. The disclosed compounds may be...