ALEXANDRIA, Va., June 6 -- United States Patent no. 12,281,310, issued on April 22, was assigned to Northwestern University (Evanston, Ill.).
"Use of trinucleotide repeat RNAs to treat cancer" was invented by Marcus E. Peter (Chicago) and Andrea E. Murmann (Chicago).
According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular disclosed are toxic RNAi active sequences such as siRNA and shRNA for killing cancer cells. The disclosed toxic RNAi active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for...