ALEXANDRIA, Va., June 18 -- United States Patent no. 12,324,828, issued on June 10, was assigned to Nektar Therapeutics (San Francisco).

"Conjugates of a factor VIII moiety having an oxime-containing linkage" was invented by Mary J. Bossard (Madison, Ala.) and Dawei Sheng (Fremont, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides conjugates comprising a Factor VIII moiety covalently attached via an oxime-containing linkage to a water-soluble polymer, such as for example, a polyethylene glycol polymer. Methods for preparing and for administering such conjugates, are also provided, as are water-soluble polymer oxyamine reagents useful for preparing the subject conjugates, a...