US Patent Issued to Navidea Biopharmaceuticals on May 13 for "CD206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker" (Massachusetts, Ohio Inventors)

ALEXANDRIA, Va., June 12 -- United States Patent no. 12,297,222, issued on May 13, was assigned to Navidea Biopharmaceuticals Inc. (Columbus, Ohio).

"CD206 targeted drug delivery vehicles carrying novel bisphosphonate drug payloads via a degradable linker" was invented by David A. Ralph (Columbus, Ohio) and Jeffrey Scott Arnold (Andover, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are novel compounds containing a polymeric carbohydrate backbone, one or more mannose-binding C-type lectin receptor targeting moieties, and a nitrogenous bisphosphonate compound coupled to the backbone via a thiol-maleimide conjugation, in addition to pharmaceutical compositions, methods of synthesizing, and meth...