US Patent Issued to National University of Singapore on Nov. 25 for "T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof" (Singaporean, Japanese Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,914, issued on Nov. 25, was assigned to National University of Singapore (Singapore).

"T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof" was invented by Dario Campana (Singapore) and Takahiro Kamiya (Tokyo).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides compositions comprising a protein expression blocker or PEBL comprising a target-binding molecule and localizing domain, and methods of using such compositions in cancer therapy. PEBLs are useful as a blockade of expression of target surface receptors (peptides or antigens) in immune cells. Also provided herein are CD3/TCRAlphaBeta-d...