US Patent Issued to National University of Singapore on March 25 for "Activating chimeric receptors and uses thereof in natural killer cell immunotherapy" (Singaporean Inventors)

ALEXANDRIA, Va., March 26 -- United States Patent no. 12,258,381, issued on March 25, was assigned to National University of Singapore (Singapore).

"Activating chimeric receptors and uses thereof in natural killer cell immunotherapy" was invented by See Voon Seow (Singapore) and Dario Campana (Singapore).

According to the abstract* released by the U.S. Patent & Trademark Office: "Current invention relates to a polynucleotide encoding activating chimeric receptors comprising engineered Natural Killer Group 2 member C (NKG2C) having enhanced affinity for HLA class I histocompatibility antigen alpha chain E (HLA-E)/peptide complex or an extracellular receptor domain of NKG2A coupled to an effector domain. It also relates to NK cells expressi...