US Patent Issued to National Research Council of Canada on March 4 for "Intrabodies for reducing FUT8 activity" (Canadian Inventors)

ALEXANDRIA, Va., March 5 -- United States Patent no. 12,240,916, issued on March 4, was assigned to National Research Council of Canada (Ottawa).

"Intrabodies for reducing FUT8 activity" was invented by Yves Durocher (Montreal) and Simon Joubert (Laval, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present document describes an alpha-(1,6)-fucosyltransferase (FUT8) antibody, antigen binding domain thereof, or a fusion protein thereof, operable to inhibit FUT8 activity in a cell, and methods of producing recombinant proteins, in particular antibodies, having reduced fucosylation. The present document also describes methods of inhibiting expression and/or activity of a protein in a cell by expressi...