US Patent Issued to Merck Sharp & Dohme on Sept. 9 for "Preparation of oxindole derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors" (California, New Jersey Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,410,159, issued on Sept. 9, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"Preparation of oxindole derivatives as novel diacylglyceride O-acyltransferase 2 inhibitors" was invented by Yeon-Hee Lim (South San Francisco, Calif.), Jianming Bao (Princeton, N.J.) and James P. Roane (Brisbane, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Invented are compounds of formula Iand the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat he...