US Patent Issued to Memorial Sloan Kettering Cancer Center on Dec. 16 for "Multimerization of IL-15/IL-15R-alpha-fc complexes to enhance immunotherapy" (New York Inventors)

ALEXANDRIA, Va., Dec. 16 -- United States Patent no. 12,497,435, issued on Dec. 16, was assigned to Memorial Sloan Kettering Cancer Center (New York).

"Multimerization of IL-15/IL-15R-alpha-fc complexes to enhance immunotherapy" was invented by Nai-Kong V. Cheung (New York) and Hong Xu (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates generally to complexes comprising an interleukin-15 ("EL-15") polypeptide chain non-covalently bonded to an IL-15 receptor Alpha-Fc fusion polypeptide ("IL-15RAlpha-Fc"), and multimers (e.g., trimers) thereof. The complexes of the present technology are useful in methods for enhancing immune cell function and immunotherapy in a patient in n...