US Patent Issued to Massachusetts Institute of Technology on April 29 for "APOE4 impairs myelination via altered cholesterol biosynthesis and transport in oligodendroglia" (American, Mexican Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,285,440, issued on April 29, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"APOE4 impairs myelination via altered cholesterol biosynthesis and transport in oligodendroglia" was invented by Joel Blanchard (Arlington, Mass.), Manolis Kellis (Boston), Li-Huei Tsai (Cambridge, Mass.), Jose Davila Velderrain (Saltillo, Mexico), Leyla Akay (Cambridge, Mass.), Djuna Von Maydell (Somerville, Mass.), Audrey Effenberger (Cambridge, Mass.) and Matheus Victor (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods of inhibiting amyloid synthesis in a subject using cyclodextrin and analogs t...