US Patent Issued to Massachusetts Institute of Technology, Ohio State Innovation Foundation on Aug. 12 for "Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy" (Massachusetts, Ohio Inventors)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,383,589, issued on Aug. 12, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.) and Ohio State Innovation Foundation (Columbus, Ohio).

"Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy" was invented by Darrell J. Irvine (Arlington, Mass.), Karl Dane Wittrup (Chestnut Hill, Mass.), Ron Weiss (Newton, Mass.), Yingzhong Li (Quincy, Mass.), Noor Momin (Cambridge, Mass.) and Yizhou Dong (Dublin, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA compr...