US Patent Issued to LEADARTIS on Oct. 28 for "Trimeric polypeptide complexes comprising a collagen XVIII homotrimerization domain and/or a collagen xv homotrimerization and an agonist of a TNFR family costimulatory receptor, encoding polynucleotide thereof and method of use thereof to treat cancer" (Spanish Inventors)

ALEXANDRIA, Va., Oct. 28 -- United States Patent no. 12,454,577, issued on Oct. 28, was assigned to LEADARTIS S.L. (Madrid).

"Trimeric polypeptide complexes comprising a collagen XVIII homotrimerization domain and/or a collagen xv homotrimerization and an agonist of a TNFR family costimulatory receptor, encoding polynucleotide thereof and method of use thereof to treat cancer" was invented by Marta Compte Grau (Madrid) and Luis Alvarez Vallina (Madrid).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to tumor-targeted trimeric polypeptides based on the homotrimerization region from collagen XV or XVIII and which contain domains capable of specifically binding to and activating receptors of...