US Patent Issued to KOS THERAPEUTICS on Dec. 2 for "Amino acid derivatives containing a disulfanyl group as an inhibitor of NEP and APN for the prevention and treatment of trigeminal nerve pain" (French Inventors)

ALEXANDRIA, Va., Dec. 2 -- United States Patent no. 12,485,104, issued on Dec. 2, was assigned to KOS THERAPEUTICS INC. (Raleigh, N.C.).

"Amino acid derivatives containing a disulfanyl group as an inhibitor of NEP and APN for the prevention and treatment of trigeminal nerve pain" was invented by Herve Poras (Villepreux, France), Tanja Ouimet (Paris), Marie Claude Fournie Zaluski (Paris), Bernard Roques (Paris) and Michel Wurm (Royat, France).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): H2N-CH(R1)-CH2S-S-CH2-CH(R2-CONH-CH(R3)-COOR4 (I) and more particularly an acid addition salt thereof, and the comp...