US Patent Issued to Jiangnan University on Sept. 16 for "Dioxygenase mutants and use thereof in synthesizing (2S,3R)-3-hydroxypipecolic acid" (Chinese Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,415,992, issued on Sept. 16, was assigned to Jiangnan University (Wuxi, China).

"Dioxygenase mutants and use thereof in synthesizing (2S,3R)-3-hydroxypipecolic acid" was invented by Yao Nie (Wuxi, China), Yan Xu (Wuxi, China), Songyin Zhao (Wuxi, China) and Jiaojiao Guan (Wuxi, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "By mutating arginine at position 97 and asparagine at position 43 of a wild type L-proline-3-hydroxylase, a mutated L-proline-3-hydroxylase is obtained. The mutated L-proline-3-hydroxylase comprises a variant of the wild-type L-proline-3-hydroxylase having SEQ ID NO:1, which comprises a substitution of the arginine correspondi...