ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,491,240, issued on Dec. 9, was assigned to JAPAN as represented by DIRECTOR GENERAL of National Institute of Infectious Diseases (Osaka, Japan) and Sumitomo Pharma Co. Ltd. (Osaka, Japan).

"Method for producing influenza HA split vaccine" was invented by Yoshimasa Takahashi (Tokyo), Yu Adachi (Tokyo) and Manabu Ato (Tokyo).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided is a method for producing an influenza HA split vaccine which produces an antibody that binds to an HA stem region of influenza, the HA stem region being less likely to cause antigenic variation, An influenza HA split vaccine is subjected to an acidic treatment. Through the acidic ...