ALEXANDRIA, Va., June 19 -- United States Patent no. 12,331,108, issued on June 17, was assigned to Institute for Research in Biomedicine (Bellinzona, Switzerland).
"Antibodies with functional domains in the elbow region between variable and constant domain" was invented by Antonio Lanzavecchia (Porza, Switzerland) and Luca Piccoli (Bellinzona, Switzerland).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides engineered antibodies and antigen binding fragments, in which an additional functional domain is inserted into the elbow region of the antibody or antigen binding fragment. The present invention also provides nucleic acid molecules, such as vectors, encoding such antibodies and a...