US Patent Issued to Indiana University Research and Technology on July 8 for "Use of APE1/Ref-1 inhibitors for treatment of retinal diseases" (Indiana Inventors)

ALEXANDRIA, Va., July 9 -- United States Patent no. 12,350,247, issued on July 8, was assigned to Indiana University Research and Technology Corp. (Indianapolis).

"Use of APE1/Ref-1 inhibitors for treatment of retinal diseases" was invented by Mark R. Kelley (Zionsville, Ind.) and Melissa L. Fishel (Fishers, Ind.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Combination therapies including a Apurinic/Apyrimidinic Endonuclease/reduction-oxidation (redox) Factor-1 (APE1/Ref-1) inhibitor specific to inhibit the redox function of APE1/Ref-1 are disclosed herein. The Combination therapies can be used for treating various cancers, as well as other angiogenesis-mediated diseases (e.g., retinal diseases, cardiovasc...