US Patent Issued to IMMUNOMEDICS on March 18 for "Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity" (Florida, New Jersey Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,251,441, issued on March 18, was assigned to IMMUNOMEDICS INC. (Foster City, Calif.).

"Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity" was invented by Serengulam V. Govindan (Springfield, N.J.) and David M. Goldenberg (Delray Beach, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. In preferred embodiments, the antibody may be an hRS7 antibody. The methods and compostions are of use to treat Trop-2 expressing cancers in human patients, preferably in p...